INVESTIGADORES
LUCANGIOLI Silvia Edith
congresos y reuniones científicas
Título:
Development of a self-emulsifying drug delivery system containing coq10
Autor/es:
ZAPICO V.,; GLUJOY M.,; BUONTEMPO F.,; FLOR S.,; LUCANGIOLI SILVIA,; CARLUCCI A.,
Lugar:
Cordoba, Argentina
Reunión:
Congreso; RICiFA 2010: 1ª Reunión Internacional de Ciencias Farmacéuticas; 2010
Institución organizadora:
RICIFA
Resumen:
Ubiquinone (CoQ10) deficiency is associated with five clinical presentations which showed clinical improvements after oral drug administration (1). Co-Q10 exhibits extreme lipophilicity and high molecular wheight, therefore it is necessary to develop special formulations for its bioavailability. It is well-known that bioavailability can significantly improve using dosage forms which contain CoQ10 dissolved (2). SEDDS (Self- emulsifying drug delivery system) are isotropic mixtures of oil, surfactant, co-surfactant and drug with ability to form oil in water emulsion upon mild agitation following dilution with aqueous phase (3). The objective of the present work was to optimize a liquid auto emulsifying formulation so as to load a clinical relevant CoQ10 dose to be administered in pediatric patients.
