Novel nano-composite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

CATTALINI JUAN; HOPPE A.; PISHBIN F; ROETHER J.; BOCCACCINI A.R.; LUCANGIOLI S.; MOURINO V.

JOURNAL OF THE ROYAL SOCIETY INTERFACE

ROYAL SOC

Lugar: Londres; Año: 2015 vol. 12

1742-5689

This work aimed to develop novel composite biomaterials for bone tissue engineering made of bioactive glass nanoparticles (Nbg) and alginate crosslinked with Cu2+ or Ca2+. Films were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the crosslinking cations and angiogenic properties. It was found that both Cu2+ and Ca2+ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both the nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage and enhance the proliferation of human umbilical vein endothelial cells which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate crosslinked with Cu2+ or Ca2+ were developed with potential applications for preparation of multifunctional scaffolds for bone tissue engineering.