INVESTIGADORES
LUCANGIOLI Silvia Edith
artículos
Título:
Coenzyme Q10 stability in pediatric liquid oral dosage formulations
Autor/es:
ESTEVEZ PABLO; TRIPODI V.; BUOMTEMPO F.; LUCANGIOLI S.
Revista:
Farmacia Hospitalaria
Editorial:
ELSEVIER
Referencias:
Lugar: Madrid; Año: 2012 vol. 36 p. 492 - 497
ISSN:
1130-6343
Resumen:
Objective: To study the stability of Coenzyme Q10 (CoQ10),
used as therapeutic agent in treatment of cardiovascular and
mitochondrial diseases, in three liquid formulations: two
soybean oil solutions (50 mg/ml), one of them with the
addition of vitamin E and an O/W emulsion (20 mg/ml) for
pediatric use. Furthermore, optimize and validate a stabilityindicating
HPLC method for the analysis of CoQ10 in the
studied formulations.To study the stability of Coenzyme Q10 (CoQ10),
used as therapeutic agent in treatment of cardiovascular and
mitochondrial diseases, in three liquid formulations: two
soybean oil solutions (50 mg/ml), one of them with the
addition of vitamin E and an O/W emulsion (20 mg/ml) for
pediatric use. Furthermore, optimize and validate a stabilityindicating
HPLC method for the analysis of CoQ10 in the
studied formulations.
Method: All samples were stored at 25°C. CoQ10 content of
each formulation was analyzed in duplicate using fast
microbore high performance liquid chromatography (Micro
HPLC) at 0, 3, 6, 15, 30, 60 and 110 days.All samples were stored at 25°C. CoQ10 content of
each formulation was analyzed in duplicate using fast
microbore high performance liquid chromatography (Micro
HPLC) at 0, 3, 6, 15, 30, 60 and 110 days.
Results: All formulations stayed stable at 25°C during the 110
days of the study. However, the oil solutions presented greater
content variations through all the study period.All formulations stayed stable at 25°C during the 110
days of the study. However, the oil solutions presented greater
content variations through all the study period.
Conclusions: The CoQ10 emulsion can be stored for at least
110 days at 25 °C and it has proven to be safer when narrow
dose adjustment is required. The proposed analytical method
was suitable for the study of stability of different formulations
meeting the validation parameters according to internationalThe CoQ10 emulsion can be stored for at least
110 days at 25 °C and it has proven to be safer when narrow
dose adjustment is required. The proposed analytical method
was suitable for the study of stability of different formulations
meeting the validation parameters according to international