DETERMINATION OF NOSCAPINE, HEXYLRESORCINOL AND ANETHOLE BY LIQUID CHROMATOGRAPHY

LUCANGIOLI S.,; FERNANDEZ OTERO G.,; RODRIGUEZ V.,; CARDUCCI C.

BOLLETTINO CHIMICO FARMACEUTICO

SOCIETA EDITORIALE FARMACEUTICA

Lugar: MILAN; Año: 1996 vol. 135 p. 387 - 390

0006-6648

A liquid chromatographic method was developed for the simultaneous separation and determination of noscapine hydrochloride, hexylresorcinol and anethole in cough lozenges. Analysis was performed on a phenyl column with phosphate buffer- acetonitrile as mobile phase and the separated components were detected at 282 mm. Recoveries obtained for the analytes were of 94.6% for noscapine hydrochloride, 99.1% for hexylresorcinol and 96.3% for anethole. The values of the relative standard deviation were 0.8% for noscapine hydrochloride, 1.5% for hexylresorcinol and 1.1% for anethole. The analytical method was validated and a system suitability test was accomplished for the chromatographic method.