INVESTIGADORES
LUCANGIOLI Silvia Edith
artículos
Título:
Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnacy
Autor/es:
CASTAÑO G.; LUCANGIOLI S.; SOOKOIAN S.,; MESQUIDA M.,; LEMBERG A.,; DI SCALA M.,; FRANCHI P.,; CARDUCCI C.; TRIPODI V.
Revista:
CLINICAL SCIENCE (LONDON, ENGLAND : 1979)
Editorial:
The Biochemical Society
Referencias:
Lugar: Londres; Año: 2006 vol. 110 p. 459 - 465
ISSN:
0143-5221
Resumen:
ICP (intrahepatic cholestasis of pregnancy) is characterized by pruritus and biochemical cholestasis,
including raised SBAs (serum bile acids) and, usually, elevated aminotransferases levels. However,
AHP (asymptomatic hypercholanaemia of pregnancy) is defined as the presence of total SBA levels
above the cut-off value (11 ìM) in healthy pregnant women, thus elevation of total SBAs do
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
ìM) in healthy pregnant women, thus elevation of total SBAs do
not necessarily reflect an ICP condition. The aim of the present study was to describe clinical,
obstetric, perinatal and biochemical findings, as well as the SBA profile, in pregnant women
studied in the third trimester of pregnancy in order to define characteristic patterns of individual
bile acids that enable women with ICP to be distinguished from AHP and healthy pregnancies. Free
and conjugated ursodeoxycholic (UDCA), cholic (CA), lithocholic (LCA), deoxycholic (DCA) and
chenodeoxycholic (CDCA) acids were evaluated by CE (capillary electrophoresis) in 41 patients
(15 of them simultaneously by HPLC), in 30 healthy pregnant women and in 10 non-pregnant
women. A highly significant correlation between CE and HPLC for total SBAs (r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.
r=0.990) and for
individual SBAs was found. Normal pregnant women had higher total SBA levels than non-pregnant
women (due to an increase in taurine-conjugated dihydroxy SBAs). Women with ICP had higher
levels of total SBAs, the free/conjugated ratio, LCA, CA, CDCA and DCA than normal pregnant
women. Newborns from women with ICP had lower birth weight and gestational age.Women with
AHP had higher levels of conjugated dihydroxy SBAs than normocholanaemic patients, without
any evidence of a clinical difference. In conclusion, the present study has shown a clear difference
in SBA profiles between ICP and normal pregnancies (including AHP), involving a shift towards a
characteristic hydrophobic composition in women with ICP.