Silica core-shell particles for the dual delivery of gentamicin and rifamycin antibiotics

MEBERT A.; AIME C. ; ALVAREZ G. ; SHI Y.; FLOR S.; LUCANGIOLI S.; DESIMONE M. ; CORADIN T.

Journal of Material Chemistry B

Royal Society of Chemistry

Lugar: Londres; Año: 2016 vol. 4 p. 3135 - 3144

2050-750X

Increasing bacterial resistance calls for the simultaneous delivery of multiple antibiotics.One strategy is to design a unique pharmaceutical carrier that is able to incorporate severaldrugs with different physico-chemical properties. This is highly challenging as it mayrequire the development of compartmentalization approaches. Here we have prepared coreshellsilica particles allowing for the dual delivery of gentamicin and rifamycin. The effectPage 1 of 37 Journal of Materials Chemistry BJournal of Materials Chemistry B Accepted Manuscript Published on 30 March 2016. Downloaded by Middle East Technical University (Orta Dogu Teknik U) on 30/03/2016 22:51:47. View Article Online DOI: 10.1039/C6TB00281A2of silica particle surface functionalization on antibiotic sorption was first studied,enlightening the role of electrostatic and hydrophobic interactions. This in turn dictates thechemical conditions for shell deposition and further sorption of these antibiotics. Inparticular, the silica shell deposition was favored by the positively-charged layer ofgentamicin coating on the core particle surface. Shell modification by thiol groups finallyallowed for rifamycin sorption. The antibacterial activity of the core-shell particles againstStaphylococcus aureus and Pseudomonas aeruginosa demonstrated the dual release andaction of the two antibiotics.