INFERTILITY IN A MODEL OF DIET-INDUCED OBESITY IN MALE B6 MICE

ALTAMIRANO L; SIMÓN LAYLA; SÁEZ E; DELLA VEDOVA MC; GOMEZ-MEJIBA SE; RAMÍREZ DC; FORNÉS MW

Mendoza

Congreso; XXXI reuniòn Cientifica Anual de la Sociedad de Biologia de CUyo; 2013

SBCuyo

Obesity and overweight are known causes of infertility in men, but the mechanism involved remains unknown. The aim of this study was to evaluate the redox profile/ inflammatory/metabolic systemic and testicular morphological abnormalities that could explain the sub-fertility. Mice model included 2 groups: LFD (low fat diet) and HFD (high-fat diet). At 18 weeks HFD group showed an increase in proinflammatory cytokines (TNF-a and IL-6) and oxidative stress markers (carbonyl and TBARS) levels. Basal fasting blood glucose and intraperitoneal glucose tolerance tests showed insulin resistance in HFD group. Epididymal fat weight was greater in HFD, and testicles showed foam cells in the interstitium. The spermato/spermiogenesis showed patchy epithelial disorganization, and abnormal spermatocytes with abnormal acrosome complex-acroplaxoma. These data suggest that the abnormalities found in spermatogenesis may be caused by changes in redox/inflammatory/metabolic status in testis, reflecting the systemic situation associated to inflammation of the adipose tissue.