IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
Relación entre niveles de selenio en sangre y diferentes patologías prostáticas
Autor/es:
LÓPEZ FONTANA CM, PÉREZ ELIZALDE R, VANRELL C, RECALDE G, UVILLA A, LOPEZ LAUR JD.
Revista:
ACTAS UROLOGICAS ESPANOLAS
Editorial:
ENE EDICIONES SL
Referencias:
Lugar: MADRID ESPAÑA; Año: 2010 vol. 34 p. 625 - 629
ISSN:
0210-4806
Resumen:
Several studies have demonstrated an inverse
relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE:
To determine and compare
selenium plasma levels in patients with different prostatic pathologies. MATERIAL
AND METHODS: It is a transversal,
descriptive and comparative study. A sample of 64 men between 50 and 80 years
old were selected for the study between 2007 and 2009. All volunteers underwent
a digital rectal examination, prostate specific antigen level, ultrasound and
transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified
according to Gleason Score. Selenium was determined indirectly by serum
Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical
analysis was performed using ANOVA I (p<0.05). RESULTS:
Glutathione Peroxidase
level was 33.75+/-2.36 mg/ml in control patients. A decrease of 31.6% was
observed in patients with BPH (23.08+/-1.57 mg/ml) and of (63.6%) in subjects
with prostate cancer (12.28+/-1.03 mg/ml) (p<0,0001). There was no
correlation with the Gleason Score. CONCLUSION: Serum Seleniun is lower in patients with prostatic
pathologies being even more important in cancer patients regardless the Gleason
Score.
La revista ACTAS UROLÓGICAS
ESPAÑOLAS esta dentro del ISI, pero todavía no tiene factor de impacto. El
factor de impacto saldrá en junio del 2011. Todos los trabajos son revisados por un Comité
de revisores antes de su publicación