IMBECU   20882
INSTITUTO DE MEDICINA Y BIOLOGIA EXPERIMENTAL DE CUYO
Unidad Ejecutora - UE
artículos
Título:
Pregnenolone sulphate infused in lateral septum of male rats impairs novel object recognition memory
Autor/es:
NANFARO, F; CABRERA, R; BAZZOCCHINI, V; LACONI, M; YUNES, R
Revista:
PHARMACOLOGICAL REPORTS
Editorial:
POLISH ACAD SCIENCES INST PHARMACOLOGY
Referencias:
Año: 2009 vol. 62 p. 265 - 272
ISSN:
1734-1140
Resumen:
In the present paper we show for the first time that pregnenolone sulfate (Preg-
S) impairs rats¡¦ memory for novel object recognition when injected in lateral
septum (1.2 ÝM). The effect of Preg-S is clearly related to the moment the
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)
ÝM). The effect of Preg-S is clearly related to the moment the
reagent is administered: If administered shortly after the training phase, or prior
to the test phase of the experiment, there is no amnesic effect. It is only
amnesic when administered 30 minutes before training. Accordingly, Preg-S
does not appear to affect the storage of new memories or their retrieval but
rather the acquisition itself. Based on the described afferences and efferences
of lateral septum we suggest a possible stimulatory effect of Preg-S regarding
glutamate receptors and/or an inhibitory effect of GABA receptors located in
local interneurons or recurrent axon collaterals, both of which have been
reported to exist in the aforementioned nucleus.
Keywords: neuroactive steroids, memory, pregnenolone sulfate, lateral septum,
novel object recognition, male rats (Sprague-Dawley)