LA ESTIMULACIÓN GABAÉRGICA DEL NÚCLEO SEPTAL LATERAL DEL CEREBRO DE RATAS MACHO INCREMENTA LA RESPUESTA AGRESIVA FRENTE A ESTÍMULOS NEUTROS.

FEDERICO NANFARO; VANESA BAZZOCCHINI; ADRIANA VEGA; FERNANDO GIULIANI; MIRIAM LACONI; SEBASTIÁN CASAS; CARLA ESCUDERO; RICARDO CABRERA; ROBERTO YUNES

Revista Médica Universitaria - F.C.M. UNCuyo

Editorial Médica Universitaria

Año: 2009 vol. 5 p. 1 - 13

1669-8991

ABSTRACT Destruction of lateral septum –a nucleus located in subcortical regions of the anterior brain– has been related to an entity known as rage septal syndrome. In the present paper we demonstrate that the direct GABAergic agonist muscimol produces “fear inhibition” when tested at non-sedative doses in Sprague-Dawley male rats. This phenomenon is also supported by an increase of aggressive behaviors directed to otherwise neutral objects. Since the septal lateral has been involved in several psychiatric diseases, it appears as potentially interesting to contribute to the knowledge of its function by taking advantage of eventual modulators known to be present in the nucleus.