CONICET | Buscador de Institutos y Recursos Humanos

Background: Imbalance in adipocytokines secretion is related to the development of metabolic syndrome (MS). In addition, moderate consumption of red wine decreases the risk of cardiovascular disease. The aim of this study was to evaluate the effects of moderate consumption of red wine (RW) or ethanol (E) on adiponectin and resistin expression, vascular inflammation, and oxidative stress in fructose-fed rats (FFR) as an experimental model of MS. Methods: Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+E (4.5 mL/kg) and F+RW (35 mL/kg of Malbec RW containing 4.5 mL/kg E). E and RW were administered during the last 4 weeks of a 10-week period. Results: RW administration to F rats was able to significantly decrease insulin resistance, mesenteric adipose tissue weight and SBP compared to F group. F+E only reduced the SBP (p<0.05 vs. F). F+RW also reduced the increased aortic NAD(P)H oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, and plasma TBARS observed in F and F+E groups (p<0.05). Adiponectin expression decreased, whereas resistin, vascular cell adhesion molecules-1 (VCAM-1) expression and vascular remodeling in mesenteric arteries were higher in F than in C group (p<0.05). Only RW was able to partially reverse the aforementioned alterations. Conclusion: In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines, attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that non-alcohol components of RW are responsible for the beneficial effects. Conclusion: In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines, attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that non-alcohol components of RW are responsible for the beneficial effects. <0.05 vs. F). F+RW also reduced the increased aortic NAD(P)H oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, and plasma TBARS observed in F and F+E groups (p<0.05). Adiponectin expression decreased, whereas resistin, vascular cell adhesion molecules-1 (VCAM-1) expression and vascular remodeling in mesenteric arteries were higher in F than in C group (p<0.05). Only RW was able to partially reverse the aforementioned alterations. Conclusion: In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines, attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that non-alcohol components of RW are responsible for the beneficial effects.