Inhibition of antigen presentation by Brucella: many more than many ways

BARRIONUEVO, PAULA; GIAMBARTOLOMEI, GUILLERMO H.

MICROBES AND INFECTION

ELSEVIER SCIENCE BV

Año: 2019

1286-4579

Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategies. We review the mechanisms whereby Brucella, through TLR signaling, inhibits MHC class I and II antigen presentation, allowing infected macrophages to become effective niches for Brucella survival.