Synthesis and Biological Evaluation of Methoxyphenyl Porphyrin Derivatives Potential Photodynamic Agents.

M.E.MILANESIO,F.MORAN,E.I.YSLAS,M.G.ALVAREZ,V.RIVAROLA, E.N.DURANTINI

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pergamon-Elsevier Science

Lugar: England; Año: 2001 vol. 9 p. 1943 - 1949

0960-894X

  A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 2',6'-dinitro-4'-trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamic activities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the photocytotoxic effect was found for 6, which has higher singlet molecular oxygen, O2(1L)g, production.