Poly(Propylene)-based Films Modified with a Tetracationic Phthalocyanine with Applications in Photodynamic Inactivation of Candida Albicans

TEMPESTI, TOMAS ; ALVAREZ, M. GABRIELA; GÓMEZ, CÉSAR; STRUMIA, MIRIAM; DURANTINI, EDGARDO N.

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING (SOFTCOVER ED.)

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2017 vol. 57 p. 166 - 174

0360-2559

Photoactive films based on polymer-like poly(propylene) (PP) were generated and utilized as support of zinc(II)tetramethyltetrapyridino[2,3-b:2´,3´-g:2´´,3´´-l:2´´´,3´´´-q]porphyrazinium salt (ZnTM2,3PyPz). Using a photograft polymerization of acrylic acid, the PP film was functionalized with carboxyl groups (PP-g-PAAc), which attached ZnTM2,3PyPz by electrostatic bond to form PP-g-PAAc-Pc films. In vitro investigations indicated that PP-g-PAAc-Pc films produced photodynamic inactivation of Candida albicans cells, mainly mediated by a contribution of type II process. According to the results, the photodynamic activity produced by the PP-g-PAAc-Pc film and visible light irradiation can successfully inactivate C. albicans deposited on the surface of the films.