INVESTIGADORES
ALVAREZ Maria Gabriela
artículos
Título:
Antifungal Activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans.
Autor/es:
TOMAS C. TEMPESTI, M. GABRIELA ALVAREZ, MARCELO FRANCISCO DE ARAÚJO, FRANCISCO EDUARDO ARAGÃO CATUNDA JÚNIOR, MÁRIO GERALDO DE CARVALHO, EDGARDO N. DURANTINI
Revista:
MEDICINAL CHEMISTRY RESEARCH
Editorial:
BIRKHAUSER BOSTON INC
Referencias:
Año: 2012 vol. 21 p. 2217 - 2222
ISSN:
1054-2523
Resumen:
In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.
