CONICET | Buscador de Institutos y Recursos Humanos

Decreased food intake ratios (RFI) in function of age were detected in a previous longitudinal study made in rats. Since the RFI decreases more in controls than in undernourished animals, an Age-of-Fitness Point (AFP), an age in which all the animals reach the same RFI could be predicted after the 80 day of age. In the present study a moderate transgenerational undernourishment was made on Wistar rats for eight generations: the first (P) being studied as controls, and the following eight as undernourished filials (F1-F8). Undernourishment was made from conception to the end of the experiment (100 days of age). The last generation was divided into two subgroups: 1) F8 undernourished as F1/F7 and 2) F8 recuperated. The recuperation process began at the 20th day and finished at the 100th day-old. The RFI in all generations was calculated in mg of food intake per gram of body weight. The aim of the present study is to determinate: 1) if the AFP varies by the effect of the transgenerational undernutrition, and if so, 2) if the AFP increases or decreases by the transgenerational effect. Additionally, 3) in which proportion the last-generation rehabilitation can reverse the transgenerational effect. Data were processed by the Repetitive Analysis of Variance. The AFP was present at the 80th day-old in females and at the 100th day-old in males, with a mean RFI of 83.5mg/g and 75.3mg/g, respectively. A non genetic cumulative effect was seen, however, through generations. The best fitted equation was, for both sexes, the quadratic polynomial y=a+bx+cx. A transgenerational RFI increment was due to the progressive body weight loss due to stressing. Differences in sex may be attributed to the well-known better canalization of the females. The one-generation rehabilitation was not enough to complete growth recovery.

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