Craniofacial catch up growth in intrauterine growth retarded rats following postnatal nutritional rehabilitation

LUNA ME ; QUINTERO FA ; CESANI MF; FUCINI MC; PRIO MV; GUIMAREY LM; OYHENART EE

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY.

I R O G CANADA, INC

Lugar: Montréal, Qué.; Año: 2014 vol. 41 p. 530 - 533

0390-6663

Purpose: The aim ofthe study was to analyze the effect of postnatal nutritional rehabilitation on the craniofacial growth in rats with intrautetine growth retardation (IUGR). Materials and Methods: Wistar rats were assigned to one of the following groups: control, Shan-operated, and IUGR. The IUGR was produced by uterine vessels bending (day 14 of pregnancy). At days 1, 21.42, 63, and 84 of postnatal life, each animal was X-rayed, and neural and facial length, width and height were measured. Volumetric and morphometric indices were calculated.Results The decreased maternal-fetal blood flow during the last-third ofthe gestation period modified cranial size and shape of both sexes at birth.Dscussion. Postnatal nutritional rehabilitation is not fUllly sufficient to reverse the prenatal growth retardation. There are specific responses depending on the sex and the age olthe IUGR pups. Regardless of the changes in size. the shape is not modified during all the postnatal period.