HDL directs activated lymphocytes to a resting phenotype

SAMPEDRO, MARÍA CECILIA; GRUPPI, ADRIANA; MOTRÁN, CRISTINA; ARTOLA, RODOLFO LUIS; KIVATINITZ, SILVIA CLARA

CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Walter de Gruyter

Año: 2003 vol. 41 p. 843 - 856

Most of the cells in the atherosclerotic plaque are  T cells, mainly CD4+ and interleukin-2 receptor+ (CD25+). High-density lipoprotein (HDL) regulates the proliferation of smooth muscle cells, but the effects on lymphocytes have not been studied yet. We studied the HDL effect on mitogen activated T-cells of human peripheral blood to determine whether HDL inhibits the proliferation of T-cells preventing their activation. T-cells of human peripheral blood (PBMC) were isolated and cultivated in the presence of phytohaemagglutinin (PHA) and HDL. HDL inhibits the proliferative response of PBMC induced by PHA, produces a diminution of the total number of T-cells without affecting CD4+/ CD8+ ratio and maintains the lymphocytes stimulated with PHA in a non-activated state, thus diminishing the expression of CD2 and CD25. HDL has a regulatory effect on T-cells hampering plaque progression