Phytochemicals as estrogen receptor modulators?- a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in the treatment of non-small cell lung cancer.

HEREÑÚ CLAUDIA BEATRIZ; CRESPO ROSANA

Translational Cancer Research

AME Publishing Company

Año: 2023

2219-6803

The proposed model for mechanisms of action involved in C. reticulata and P. ternata-inducedNSCLC growth inhibition would be the modulation of the nuclear receptor (ESR1)—co-repressor (NCOA3) complex in control of cell cycle via c-Fos transcription factor. As concluding remarks, the antiproliferative effect of phytocompounds from medicinal plants through the modulation of ERs, specifically in lung cells, is a promising mechanism of action that could provide scientific information to find new therapeutic targets.