IIB   20738
INSTITUTO DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
Autor/es:
MENDIETA, J.; FIMOGNARI, C.; DALEO, G. R.; REHÍLA, P.; GUEVARA, M. G.
Revista:
FITOTERAPIA
Editorial:
Elsevier
Referencias:
Año: 2010 vol. 81 p. 329 - 335
ISSN:
0367-326X
Resumen:
StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and
spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
APs are potato aspartic proteases with cytotoxic activity against plant pathogens and
spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect
on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert
cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no
significative effect on the T lymphocytes viability was observed at all StAPs incubation times
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer therapy
leads for cancer therapy
and concentrations tested. These results suggest that StAPs can be conceptually promising
leads for cancer th