INVESTIGADORES
ELISSONDO Maria Celina
artículos
Título:
Could beta-myrcene be an alternative to albendazole for the treatment of experimental cystic echinococcosis?
Autor/es:
FABBRI J, ; MAGGIORE M, ; PATRICIA PENSEL; ALBANI C,; GUILLERMO M. DENEGRI; ELISSONDO, MARÍA CELINA
Revista:
ACTA TROPICA
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2018 vol. 187 p. 5 - 12
ISSN:
0001-706X
Resumen:
Echinococcus granulosus causes hydatidosis or cystic echinococcosis in humans and livestock. In humans, this disease can be managed with surgery, percutaneous treatment, chemotherapy and/or observation. The chemotherapeutic agents used and approved for treatment of hydatidosis are benzimidazoles. Because of thedifficulties in achieving successful treatment, considerable efforts have been made to find new natural compounds against hydatid disease. Beta-myrcene is a monoterpene presented in the essential oils of different plants. It is theprincipal component of essential oil of Rosmarinus officinalis (rosemary). The goal of the present study was to evaluate the in vitro effects of beta-myrcene against germinal cells, protoscoleces and murine cyst of E. granulosus, aswell also, investigate its chemoprophylactic activity in a murine model of cystic echinococcosis. For the in vitro assays, the parasites were incubated with beta-myrcene at 10, 5 and 1 μg/mL. The treatments were dose and time-dependent, and consistent with the observed morphological alterations. In the chemoprophylactic efficacy study, the effect of betamyrcene was similar to albendazole, the reference drug for human echinococcosis treatment.