Seminal parameters from patients chronically treated with low or moderate doses of aspirin-like drugs

MOLINA RI; MARTINI AC; TISSERA A; RUIZ RD; ESTOFÁN D; FIOL DE CUNEO M

Montevideo, Uruguay

Congreso; VII Congreso Internacional de la Federación Latinoamericana de Sociedades de Esterilidad y Fertilidad; 2002

Federación Latinoamericana de Sociedades de Esterilidad y Fertilidad

  Objetive: To evaluate sperm quality in male patients attending an infertility clinic, who declare taking aspirin and/or other NSAIDs by self-medication (without diagnosed illness) for at least six months in different frequency and doses.  Design: Data for two years were retrospectively analyzed. Setting: Andrological and Reproductive Laboratory (LAR), Córdoba, Argentine. Patients: One thousand three hundred seventy six patients that according to the NSAIDs doses taken were grouped as follows: control (no NSAIDs consumption), group A (1-4 pills NSAIDs/month), group B (5-9 pills NSAIDs/month), group C (10-20 pills NSAIDs/month) and group D (at least one pill/day). Results: An impairment was found in the seminal quality of group D with respect to seminal volume (vs Control, group A and group B), sperm motility and the percentage of gametes morphologically normal (vs Control and group A), and seminal fructose concentration and sperm viability (vs Control). A negative correlation was found between NSAIDs doses and seminal volume, a-glucosidase levels, sperm motility and normal morphology while a positive correlation was found with the percentage of dead spermatozoa. Conclusions: A possible deleterious effect of low or moderate doses of NSAIDs chronically administered on male reproductive functions is evidenced by our study.