Obesity and sperm quality: effect of physical exercise and ghrelin.

MACHUCA D; GUANTAY P; TORRES PJ; RAMÍREZ ND; ARJA A; MARTINI AC (DEBE SER CONSIDERADA ÚLTIMO AUTOR CONJUNTO); LUQUE EM

Córdoba

Jornada; XXIV Jornada de Investigación de la Facultad de Ciencias Médicas.; 2023

Secretaría de Ciencias y Tecnología - Facultad de Ciencias Médicas - UNC

Obesity is the most prevalent metabolic disease worldwide. It is described as a situation of “meta-inflammation”, with dyslipidemia, hypertension, cardiovascular disease and premature mortality as recurrent hallmark. The hypothesis of our study was that “in rats, physical exercise (PhyExc) and/or Ghrelin (Ghrl) can improve the metabolic profile and the quality of the spermatozoa that were impaired by obesity”. To do this, applying an obesogenic diet (ObD: pelleted food +30% pork fat+water with 5% fructose) to male Wistar rats from weaning (day 21), we aimed to study the evolution of body weight and, in adulthood, the metabolic profile, visceral fat mass and sperm quality. We also evaluated whether the application of regular PhyExc (walking on standardized wheels, 15 min/day, 3 day/week from day 65 to 103) and/or Ghrl (6 nmol/animal/day s.c. from day 85 to 103), modified the results. Animals were divided in 5 groups: a) control diet (CD): pelleted food+ water, b) ObD, c) ObD+Ghrl, d) ObD+PhyExc and e) ObD+Ghrl+PhyExc. Results were statistically evaluated by ANOVA, considering p