Functional activity of mouse sperm was not affected by low doses of aspirin-like drugs.

STUTZ G; MARTINI AC; RUIZ RD; FIOL DE CUNEO M; MUÑOZ L; LACUARA JL

ARCHIVES OF ANDROLOGY

Taylor and Francis

Lugar: Filadelfia- EEUU; Año: 2000 vol. 44 p. 117 - 128

0148-5016

  In order to investigate some possible effects of low doses of nonsteroidal anti-inflammatory drugs upon functional activity of mouse spermatozoa, we injected lysine acetyl salicylate (i.m. 14.3 mg/kg/day), ibuprofen (i.p. 5.6 mg/kg/day) or piroxicam (i.p. 0.28 mg/kg/day) to pregnant females (the male cohort was sacrificed at adulthood) (A) or to adult males during 35 (B) or 60 (C) days. Parameters measured were: motility, viability, acrosomal integrity, responses to hypoosmotic shock, in vitro fertilization index and testosterone plasma levels. Salicylate evoked a slightly reduction in the percentage of swollen gametes in A and ibuprofen diminished testosterone plasma levels in B. The others parameters remained unchanged in all groups. Results are well supported by the low doses assayed, which are equivalent to the content of one tablet commercially available for each compound.