INVESTIGADORES
LUNA Julio Alberto
artículos
Título:
Use of chitosan membranes to mimic human epidermis for the development of an estradiol delivery system.
Autor/es:
LUCIANO MENGATTO,; DR. JULIO A. LUNA; DRA. MARÍA I. CABRERA
Revista:
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Editorial:
J Pharm Innov
Referencias:
Año: 2011 p. 241 - 248
ISSN:
0344-4325
Resumen:
Polymeric membranes with skin-mimetic permeability
properties appear as attractive models for use in the
development of transdermal drug delivery systems. These
membranes can be placed in contact with the transdermal
system and simulate the skin barrier. In the current work,
statistical experimental design was implemented for preparation
of the optimized chitosan membrane to mimic
human epidermis. For this purpose, an optimization process
based on response surface methodology was carried out in
order to determine the best combination of independent
factors for membrane preparation. The independent factors
analyzed were concentration of chitosan, concentration of
cross-linking agent, and cross-linking time. The optimized
membrane successfully simulated the cumulative amount of
estradiol released per unit time for human epidermis. In
addition, the optimized membrane was evaluated for the
development of an estradiol delivery system. This in vitro
technology may offer an alternative methodology for the
development of transdermal delivery systems.
