Multielemental analysis with x-ray microfluorescence in mammary gland tumour of mice treated with omega-3 fatty acid

SBARATO, V.; PÉREZ, R.D.; FALCHINI, G.E.; PASQUALINI, M.E.; COMETTO VINCENTE, F.; SORIA, E.A.

Mar del Plata

Encuentro; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica - SAIC; 2019

The Salvia hispanica L., whose common name is Chia, is an annual herbaceous plant belonging to the Lamiaceae family. Chia seeds have been investigated and recommended due to their high levels of essential fatty acids with the highest proportion of omega-3 fatty acid (w3-FA) compared to other natural sources known to date. It is well known that the consumption of w 3-FA can slow or stop the growth of cancer cells. This work contains the preliminary results of our study about the effects of Chia oil (ChO) in a murine mammary gland adenocarcinoma by micro-X ray fluorescence (micro-XRF) analysis. The histological and multielemental analysis by micro-XRF has been combined to infer information about the mechanisms related with the anti-tumorigenic actions of w3-FA. The objective of this work is to map the spatial distribution and quantification of certain chemical elements in mammary gland tumor samples inoculated in mice that presented a special diet with Chia and compare it with the control samples. It will also identify chemical elements that present variations and that would behave as biomarkers and that allow elucidating the role of omega 3 fatty acids in metabolic processes in relation to cancer.