CONICET | Buscador de Institutos y Recursos Humanos

Human ventricles have complex anatomical endocardial structures, such as papillary muscles, trabeculations and false tendons(FT), and there is high heterogeneity in these sub-structures configuration. However, detailed endocardial structures are often excluded in most of electrophysiological (EP) simulations, which consider smooth-walled ventricles. Another source of heart variability never considered in EP simulations are the fundamental gender differences, as female hearts have a reduced repolarization reserve. The aim of this work is to analyse the influence of both highly detailed anatomical endocardial structures and gender phenotype on the EP of four biventricular, anatomically normal human heart models. Furthermore, a comparison to smoothed-endocardium geometries is done to quantify the errors introduced by neglecting such structures.