Internal dosimetry for alpha emitters radiopharmaceuticals in biological tissue studied with the FLUKA code

M. VALENTE; F. MALANO; P. PEREZ

MONTEVIDEO

Simposio; X LASNPA; 2014

UNIVERSIDAD DE LA REPUBLICA URUGUAY

Nuclear medicine clinical practices for neoplasic disease diagnose and treatment are based on theincorporation of α, β and γ radiotracers and radiopharmaceuticals, which might be associatedwith potential damage. Thus, being necessary accurate dosimetry strategies. In vivo absorbeddose appears as an ideal solution. However, its implementation in clinics does not attain enoughreliability. In this sense, different approaches were proposed for internal dosimetry calculations.This work presents a novel analytical-numerical approach for internal dosimetry purposes. Ded-icated Monte Carlo simulations were performed by subroutines adapted from the FLUKA code.In-water EDK were evaluated at different photon energies and some typical γ-emitters radiophar-maceuticals; whereas DPK were obtained for both α- and β - emitters. Additionally, EDK andDPK were calculated for several biological tissues.