Dosimetry Optimization System and Integrated Software (DOSIS): a comparison against Fluka code results over a standard phantom

P. PEREZ; F. BOTTA; M. CREMONESI; M. FERRARI; F. GUERRIERO; A. MAIRANI; F. MALANO; G. PEDROLI; I. SCARINCI; M. VALENTE

MONTEVIDEO

Simposio; X LASNPA; 2014

UNIVERSIDAD DE LA REPUBLICA URUGUAY

Presently available technology like dual-imaging facilities allow obtainance of both mass andactivity patient-specific distributions perfectly correlated, which are important to improve dosedistributions estimations and radioimmunotherapy treatment planifications accuracy. Approachesfor internal dosimetry at voxel level require both quantitative and qualitative validation in orderto effectively improve patient-specific dose assessment.The present work presents advances on the development of a novel computational tool dedicatedto 3D patient-specific dosimetry. The final goal of the main project is to develop and bench-mark an integral calculation tool for the wide range of available medical practices in nuclearmedicine. The objetive is to provide reliable and accurate tools for planar and tridimensionalinternal dosimetry approaches. The developed model for planar dosimetry is based on a deter-ministic approach; whereas it is employed a platform based on full-stochastic methods aimed to3D dosimetry for α-, β - and γ-emitters used in radiopharmaceutical applications. DOSIS is baseddirectly on the Boltzmann radiation transport equation to realize energy delivering calculations.Procedures for 2D and 3D dosimetry are designed in the framework of MIRD formalisms andstandards. Specific modules manage both anatomic and metabolic patient-specific images and thededicated packages provide comfortable dose distribution visualization.DOSIS has been preliminary validated on some typical clinic cases by comparison whith standardroutine procedures commonly used in radioimmunotherapy. Preliminary comparisons show ac-cordance between DOSIS and methods of daily use in clinics. Besides, it was observed that theDOSIS toolkit actually attains the goal of being comfortable and user friendly. Finally, tests overstandard phantoms are performed using the DOSIS toolkit and FLUKA code. Thus, assessingpreliminary evidence about the radiation transport model developed for DOSIS.