IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Improving the Stability and the Pharmaceutical Properties of Norfloxacin Form C Through Binary Complexes with β-Cyclodextrin
Autor/es:
CHATTAH, ANA KARINA; LONGHI, MARCELA; ALOISIO, CAROLINA; GARNERO, CLAUDIA; FABIETTI, LUIS; CHATTAH, ANA KARINA; LONGHI, MARCELA; ALOISIO, CAROLINA; GARNERO, CLAUDIA; FABIETTI, LUIS
Revista:
AAPS PHARMSCITECH
Editorial:
SPRINGER
Referencias:
Año: 2018 vol. 19 p. 2255 - 2263
ISSN:
1530-9932
Resumen:
Norfloxacin, an antibiotic that exists in different solid forms, has very unfavorable properties in terms of solubility and stability. Binary complexes of norfloxacin, in the solid form C, and β-cyclodextrin were procured by the kneading method and physical mixture. Their effect on the solubility, the dissolution rate, and the chemical and physical stability of norfloxacin was evaluated. To perform stability studies, the solid samples were stored under accelerated storage conditions, for a period of 6 months. Physical stability was monitored through powder X-ray diffraction, high-resolution 13C solid-state nuclear magnetic resonance, and scanning electron microscopy. The results showed evidence that the kneaded complex increased and modulated the dissolution rate of norfloxacin C. Furthermore, it was demonstrated that the photochemical stability was increased in the complex, without affecting its physical stability. The results point to the conclusion that the new kneading complex of norfloxacin constitutes an alternative tool to formulate a potential oral drug delivery system with improve oral bioavailability.