Discretization of gene expression data revised

GALLO, CRISTIAN A.; CECCHINI, ROCÍO L.; CARBALLIDO, JESSICA A.; MICHELETTO, SANDRA; PONZONI, IGNACIO

BRIEFINGS IN BIOINFORMATICS

OXFORD UNIV PRESS

Lugar: Oxford; Año: 2016 vol. 17 p. 758 - 770

1467-5463

Gene expression measurements represent the most important source of biological data used to unveil the interaction and functionality of genes. In this regard, several data mining and machine learning algorithms have been proposed thatrequire, in a number of cases, some kind of data discretization to perform the inference. Selection of an appropriate discretization process has a major impact on the design and outcome of the inference algorithms, as there are a number ofrelevant issues that need to be considered. This study presents a revision of the current state-of-the-art discretization techniques, together with the key subjects that need to be considered when designing or selecting a discretization approach for gene expression data.