E2F transcription factors and their complementary roles during DNA damage responses

CASATI, PAULA

MOLECULAR PLANT

OXFORD UNIV PRESS

Año: 2023

1674-2052

E2F TFs (E2FA–F), which are classified as typical (E2FA–C) and atypical (E2FD–F) depending on their ability to interact with two DP interaction proteins (DPa and DPb) ( Sablowski and Gutierrez, 2022 ). While E2FA–C need to heterodimerize with either DPa or DPb to function, E2FD–F act independently of DP proteins. Moreover, the retinoblastoma-related1 (RBR1) protein also binds and inhibits the typical E2F/DP TF complexes when bound to the promoter of genes, repressing their expression in the absence of a signal to enter a new cell cycle. In general, E2FA and E2FB are considered transcriptional activators, while E2FC is generally considered a repressor of cell proliferation ( Sablowski and Gutierrez, 2022 ). In addition, it is well documented that E2FB at least, and probably E2FA, can also stimulate the G2/M transition.