Emerging mechanisms in neuronal signaling: from cell biology to pathogenesis

GUIDO, MARIO E.; SALVADOR GABRIELA; ALONSO, ALEJANDRA DEL CARMEN

Frontiers Editorial

Lugar: Laussane; Año: 2019 p. 452

978-2-88966-111-4

Unraveling the molecular processes involved in the genesis, differentiation, and cell death of thenervous system is an intense and continual interest of the neuroscience community. In recent years,the preponderance of research focused upon signal transduction mechanisms relying on proteincascades, but more information is needed on the role and function of other molecular mechanisms.These molecular mechanisms include but not limited to: lipid mediators (sphingolipids, fatty acids,glycerophospholipids, etc.), lipid-binding proteins (ApoD, PPAR, etc.), protein-lipid interactions(c-Fos-lipid synthesizing enzymes), protein misfolding and not fully characterized membraneproteinreceptors. Signal transduction events triggered by bioactive lipids and related transcriptionfactors (immediate early genes, metabolic regulators, etc.) now receive special attention as animportant nodal regulatory process. Deregulation of lipid-mediated processes is also linked toneurodegenerative diseases [Parkinson (PD), Alzheimer (AD), and retinopathies] and proliferativedisorders (brain cancer and diabetic retinopathy). Moreover, the modern lifestyle (hypercaloricdiets, continuous artificial light exposure, sedentary life, aging, stress) impacts on lipid signalingand metabolism, and can alter brain function, physiology, and behavior. Focused on thisbroad spectrum of underlying mechanisms related to molecular and cellular neuroscience, aResearch Topic call elicited expansive, research interest and submissions from among internationallaboratories. As a result of this interest, 33 contributions are accepted and published on themolecular mechanisms as described above. One hundred and fifty-eight authors from researchlaboratories located in nine countries: North and South America (Argentina, Canada, Chile, andUSA), Asia (China), and Europe (France, Poland, Spain, Switzerland), contributed to the accepted,peer-reviewed articles.