Control of fed-batch bioreactors

PICÓ, J.; PICÓ-MARCO, E.; NAVARRO, J.; DE BATTISTA, H.

Nonlinear and Adaptive Control: Theory and Algorithms for the User

Imperial College Press

Lugar: Londres; Año: 2005; p. 207 - 237

This chapter addresses the control of microbial speci_c growth rate in fedbatch bioreactors. Practical constraints concerning the available signals and information on the process are dealt with. Then, for a large class of bioreactions, namely pure cultures with one limiting substrate and oxygen in excess, the control problem is regarded as a problem of coordinating control involving the invariance and attractivity of nontrivial sets in state space. Both monotonous and non-monotonous kinetic functions are dealt with. The dissolved oxygen signal can give valuable information about the cell culture, when the oxygen supply is in balance with the consumption.