Population genetic analysis of 15 autosomal STRs loci in the central region of Argentina

MIGUEL MARINO,; ANDREA SALA; CORACH DANIEL

FORENSIC SCIENCE INTERNATIONAL.

Elsevier

Lugar: Ireland; Año: 2006 vol. 161 p. 72 - 77

0379-0738

Population genetic analysis of 15 autosomal STRs loci in the central region of Argentina Miguel Marino, Andrea Sala and Daniel Corach, Servicio de Huellas Digitales Genéticas and Cátedra de Genética y Biología Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina Received 23 June 2005;  revised 1 August 2005;  accepted 23 August 2005.  Available online 26 September 2005. Abstract Allele frequencies, together with some parameters of forensic interest, for 15 STRs included in the Powerplex-16 System (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, Penta D, Penta E, TH01, TPOX and VWA) were estimated from a sample set of 1368 unrelated individuals from three of the most densely populated provinces of Argentina. No deviations from Hardy–Weinberg equilibrium were observed using the Bonferroni correction for the number of loci analyzed. Comparative analyses between our population data and that of other Argentinean databases previously published are presented and discussed. The most informative loci in our data set is the Penta E Loci with discrimination power larger than 0.98 and typical paternity index larger than 4.3. Our results demonstrate that these loci are robust since different laboratories and sample sets provided highly consistent results. This observation underscores the usefulness of these markers systems for human identification and parentage testing. Keywords: Forensic sciences; Autosomal STR; Population genetics; Buenos Aires; Santa Fe; Mendoza; Argentina