INVESTIGADORES
SALA Adriana Andrea
artículos
Título:
Amerindian mitochondrial DNA haplogroups predominate in the population of Argentina: towards a first nationwide
Autor/es:
BOBILLO MC; ZIMMERMANN; SALA A; ROCK; BANDELT; CORACH D; PARSON W
Revista:
INTERNATIONAL JOURNAL OF LEGAL MEDICINE.
Editorial:
SPRINGER
Referencias:
Lugar: Viena; Año: 2010 vol. 124 p. 263 - 268
ISSN:
0937-9827
Resumen:
The study presents South American mitochondrial
DNA (mtDNA) data from selected north (N=98), central (N=
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
N=98), central (N=
193) and south (N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
analysis of the complete mtDNA control region (CR, 16024
N=47) Argentinean populations. Sequence
analysis of the complete mtDNA control region (CR, 16024
576) resulted in 288 unique haplotypes ignoring C-insertions
around positions 16193, 309, and 573; the additional
analysis of coding region single nucleotide polymorphisms
enabled a fine classification of the described lineages. The
Amerindian haplogroups were most frequent in the north and
south representing more than 60% of the sequences. A
slightly different situation was observed in central Argentina
where the Amerindian haplogroups represented less than
50%, and the European contribution was more relevant.
Particular clades of the Amerindian subhaplogroups turned
out to be nearly region-specific. A minor contribution of
African lineages was observed throughout the country. This
comprehensive admixture of worldwide mtDNA lineages
and the regional specificity of certain clades in the
Argentinean population underscore the necessity of carefully
selecting regional samples in order to develop a nationwide
mtDNA database for forensic and anthropological purposes.
The mtDNA sequencing and analysis were performed under
EMPOP guidelines in order to attain high quality for the
mtDNA database.