TP53 polymorphism codon 72 in oral cancer and oral potentially malignant disorders in Argentina patients

ZARATE, A. M.; SECCHI, D.; CARRICA, A.; BARRA, J. L.; BRUNOTTO, M.

Rhodes Islands

Congreso; 4th World Congress of the International Academy of Oral Oncology (IAOO).; 2013

The tumor suppressor gene presents a common polymorphism at codon 72, encoding proline or arginine. These variants could modify biological functions and are related to geographic latitude. Purpose: Our purpose was to evaluate the prevalence and possible relationship to both alleles with oral carcinoma (Ca), oral potentially malignant disorders (OPMD) or other stomatological (Con) lesions in adult patients.Our purpose was to evaluate the prevalence and possible relationship to both alleles with oral carcinoma (Ca), oral potentially malignant disorders (OPMD) or other stomatological (Con) lesions in adult patients. Material and methods: Cross-sectional study was designed, the 43 patients, both genders, aged 36?80 years were recruited at Dentistry Faculty of Cordoba, Universidad Nacional de Córdoba?Argentina. The detection of polymorphism at codon 72 was performed with the allele specific PCR.Cross-sectional study was designed, the 43 patients, both genders, aged 36?80 years were recruited at Dentistry Faculty of Cordoba, Universidad Nacional de Córdoba?Argentina. The detection of polymorphism at codon 72 was performed with the allele specific PCR. Results: We observed 33% of OPMD, 28% of Ca and 39% of Con; and the male was presented higher percentage of Ca (35%) in relation to female with Ca (25%), however the inverse relationship was observed with patients diagnosed with OPMD. The homozygous or heterozygous status are high significant (p = 0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%).We observed 33% of OPMD, 28% of Ca and 39% of Con; and the male was presented higher percentage of Ca (35%) in relation to female with Ca (25%), however the inverse relationship was observed with patients diagnosed with OPMD. The homozygous or heterozygous status are high significant (p = 0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%).p = 0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%). Conclusions: therefore, evidence of association among homozygosity/ heterozygosity for p53 arginine or proline and premalignant and malignant lesions in our population sample. It is known that the accumulated number of variants on the same chromosome could be additive or multiplicative for changes in function of p53 gene and leading to increase the malignity risk.therefore, evidence of association among homozygosity/ heterozygosity for p53 arginine or proline and premalignant and malignant lesions in our population sample. It is known that the accumulated number of variants on the same chromosome could be additive or multiplicative for changes in function of p53 gene and leading to increase the malignity risk.