Effect of ursodeoxycholic acid treatment on hepatic glucuronidation in ethynylestradiol-induced cholestasis

SANCHEZ POZZI, EJ; CATANIA, VIVIANA A; ROMA, MARCELO G; LUQUITA, MG; RODRÍGUEZ GARAY, EMILIO A; MOTTINO, AD

Pregnancy, sex hormones and the Liver (Falk Simposium Nº 89)

Kluwer Academin Publisher

Lugar: Dordrecht, Germany; Año: 1996; p. 243 - 244

UDC is employed for the treatment of several cholestatic diseases. In the rat, UDC has shown beneficial effects in cholestasis induced by ethynyloestradil (EE). However, little is known about how UDC affects metabolism in this condition.AIM: evaluate, in EE-cholestatic rats, the effects of UDC treatment on glucuronidation of different substances: bilirubin, an endobiotic, p-nitrophenol, a xenobiotic and EE, whose 17ß-glucuronide has proved to be a potent cholestatic.Conclusion: The results suggested that glucuronidation was nonspecifically impairted by UDC in EE-cholestasis, raising the possibility that a least part of UDC beneficial effects may be mediated by a decrease in the production of cholestatic derivativs such as EE-17ß-glucuronide