Enhancement of cytosolic and microsomal glutathione S-transferase activities in liver and small intestine from female rats during lactation.

LUQUITA, MARCELO G; CATANIA, VIVIANA A; ENRIQUE JUAN SANCHEZ POZZI; MOTTINO, ALDO D

PHARMACOLOGY AND TOXICOLOGY

Munksgaard

Año: 1995 vol. 76 p. 72 - 75

0901-9928

The influence of lactation on hepatic and intestinal glutathione S-transferase activities in mother rats was studied. Cytosolic and microsomal activities were assessed 7, 14 and 21 days after delivery, using 1-chloro-2,4-dinitrobenzene as substrate. Cytosolic and microsomal activities from liver and small intestine determined 7 days post partum did not differ from those of virgin female rats. The hepatic cytosolic activity was significantly increased with respect to that of virgin females 14 days after delivery and tended to revert to the control value on day 21 of lactation, whereas the intestinal activity was increased on day 14 and remained augmented even 21 days post partum. Although the respective microsomal activities showed percent increases higher than those of the cytosolic enzymes, they both exhibited a similar pattern of stimulation in response to lactation.