INVESTIGADORES
PELLIZAS Claudia Gabriela
artículos
Título:
Control of dendritic cell maturation and function by triiodothyronine (T3)
Autor/es:
MASCANFRONI ID; MONTESINOS MM; SUSPERREGUY S; CERVI L; ILARREGUI J; RAMSEYER V; MASINI-REPISO AM; TARGOVNIK HM; RABINOVICH GA; PELLIZAS CG
Revista:
FASEB JOURNAL
Editorial:
The Federation of American Societies for Experimental Biology
Referencias:
Lugar: New York, USA; Año: 2008 vol. 22 p. 1032 - 1042
ISSN:
0892-6638
Resumen:
Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs)
in the initiation of adaptive immune responses has not
yet been examined. Here we investigated the presence
of thyroid hormone receptors (TRs) and the impact of
THs in the physiology of mouse dendritic cells (DCs),
specialized antigen-presenting cells with the unique
capacity to fully activate naive T cells and orchestrate
adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs
at mRNA and protein levels, showing a preferential
cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression
of DC maturation markers (major histocompatability
complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated
the ability of DCs to induce naive T cell proliferation
and IFN- production in allogeneic T cell cultures.
Analysis of the mechanisms involved in these effects
revealed the ability of T3 to influence the cytoplasmicnuclear shuttling of nuclear factor-B on primed DCs.
Our study provides the first evidence for the presence
of TRs on bone marrow-derived DCs and the ability of
THs to regulate DC maturation and function. These
results have profound implications in immunopathology, including cancer and autoimmune manifestations
of the thyroid gland at the crossroads of the immune
and endocrine systems.