INVESTIGADORES
SERRA Esteban Carlos
artículos
Título:
Update on the Biological Relevance of Lysine Acetylation as a Novel Drug Target in Trypanosomatids
Autor/es:
MARTINEZ PERALTA, GONZALO; ESTEBAN SERRA; ALONSO VL
Revista:
CURRENT MEDICINAL CHEMISTRY.
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park; Año: 2022
ISSN:
0929-8673
Resumen:
The number of acetylated proteins identified from bacteria to mammals hasgrown exponentially in the last ten years, and it is now accepted that acetylation is a key component in most eukaryotic signaling pathways and is as important as phosphorylation. The enzymes involved in this process are well described in mammals; acetyltransferases and deacetylases are found inside and outside the nuclear compartment and have different regulatory functions. In trypanosomatids, several of these enzymes have been described and are postulated to be novel antiparasitic targets for the rational design of drugs. In this review article, we present an update of the most important known acetylated proteins in trypanosomatids, analyzing the acetylomes available. Also, we summarizethe information available regarding acetyltransferases and deacetylases in trypanosomes and their potential use as chemotherapeutic targets.
