INVESTIGADORES
SERRA Esteban Carlos
artículos
Título:
Characterization of a Biomphalaria glabrata Receptor for Activated Protein Kinace C (BgRACK)
Autor/es:
LARDANS, VINKA; ESTEBAN SERRA; DISSOUS, COLETTE
Revista:
EXPERIMENTAL PARASITOLOGY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 1998 vol. 88 p. 194 - 199
ISSN:
0014-4894
Resumen:
A receptor for activated protein kinase C (RACK) was characterized from the mollusc Biomphalaria glabrata, the intermediate host for the human parasite Schistosoma mansoni. This protein was shown to possess structural and functional characteristics of other RACK proteins from various cells and organisms. Its ability to bind mammalian PKCs also confirmed the conservation of PKC and RACK interactive domains throughout evolution. Results of immunolocalization indicated the presence of Bg RACK in the cytoplasm of mollusc hemocytes and B. glabrata embryonic (Bge) cells with a more intense staining around the nucleus. These results are in agreement with the association of RACK proteins with cytoskeletal elements.
