Crystal structure and biological properties of (±)-3,6-di-o-(2-propylpentanoyl)-1,2:4,5-di-o-isopropylidene-myo-inositol

G. E. ECHEVERRÍA; G. PUNTE; J. A. ELLENA; S. C. MOON; L. E. BRUNO-BLANCH

uerto Madryn – Chubut

Congreso; II Reunión de la Asociación Argentina de Cristalografía; 2006

  Selectively protected myo-inositol chemistry has achieved intense interest since the recognition of the many biological implications of inositol. After the discovery, in 1983, that inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) is a Ca2+-mobilizing second messenger,[1] a great effort was dedicated during the eighties to the synthesis of inositol phosphates, some of them have shown to be components of cells. It followed, during the 1990s an interest on the lipid phase and this century has witnessed a renewed interest in the phosphates derivatives.[2] Diketals of myo-inositol are very important intermediates to prepare the different inositol phosphate derivatives.[3]