INVESTIGADORES
ECHEVERRIA Gustavo Alberto
artículos
Título:
Green Biphasic Synthesis, X-Ray Diffraction Structure and Conformational Analysis of O-Glycosylmethyl Isoxazoles: Potential Substrates of GLUT-1 Glucose Transporter.
Autor/es:
LE PORS, MACARENA S.; BARRI, IVAN A.; RIAFRECHA, LEONARDO E.; ECHEVERRÍA, GUSTAVO A.; PIRO, OSCAR E.; COLINAS, PEDRO A.
Revista:
ChemistrySelect
Editorial:
John Wiley and Sons Inc
Referencias:
Año: 2022 vol. 7
Resumen:
An efficient synthesis of new 1-O-β-glycosylmethyl isoxazoles is described. The title compounds are obtained by cycloaddition of nitrile oxides generated in situ in 2-MeTHF/sodium hypochlorite solution. The developed approach provides the first use of this green methodology to prepare isoxazole derivatives. X-ray diffraction structure and conformational analysis in solution show that glycosyl isoxazoles possess the structural features required to be substrates of GLUT-1.
