CIRCULATING HEAT SHOCK PROTEIN 27 (HSPB1) LEVELS IN PREDICTION OF PREECLAMPSIA: A PILOT STUDY

MARTÍN RL; SOTTILE ML; REDONDO AL; GOMEZ LC; GAUNA GV; FLAMINI MI; GRAJEDA C; ANZALONE AC; RODRIGUEZ ECHANDÍA E.; NADIN SB; VARGAS ROIG LM

International Journal of Gynecology & Obstetrics

Wiley

Año: 2021

1879-3479

Objective: Although numerous proteins have been proposed for diagnosis of Preeclampsia (PE), such as the placental protein 13 (PP13), no biomarker was able to predict the development of PE at early stages yet. This study aimed to determine whether circulating heat shock proteins HSP27/HSPB1 and HSP90α/HSPC1 may be useful for early predicting the occurrence of PE in asymptomatic women.Methods: We have measured by ELISA the levels of HSPB1, HSPC1 and PP13 in serum samples from 44 patients at first trimester (10-12 weeks) and second trimester (17-20 weeks) of gestation. Western blot and immunohistochemistry for HSPB1 and HSPC1 were performed. Results: HSPB1 serum levels were higher in PE patients than in normotensive pregnant women at the first and second trimester (P=0.003), while PP13 levels decreased in PE patients only in the first trimester of gestation (P=0.021). We also observed higher HSPB1 levels in patients with early-onset PE in the first and second trimester (P=0.014). Conclusion: This pilot study points out that circulating HSPB1 levels in first and second trimester might be useful for predicting the occurrence of PE in asymptomatic women. Further validation studies are needed to finally establish this protein as candidate predictive biomarker of PE.