Batch Process Development: from Reactions to Manufacturing Systems

GEORGE STEPHANOPOULOS,; SHAHIN ALI,; ANDREAS LINNINGER,; ENRIQUE SALOMONE

COMPUTERS AND CHEMICAL ENGINEERING

Pergamon Elsevier Ltd

Lugar: Oxford; Año: 1999 vol. Supp p. 975 - 984

0098-1354

Development of batch processes is quite different from that practiced for continuous processes. Highly desired short development cycles, the multitude of products under development and the continuous adaptation of existing products, the broad range of scientific knowledge and engineering expertise that must be brought together, are some of the features that call for different development paradigms. In this paper we examine the nature of batch process development, its phases and the needs for each phase, the requisite knowledge, and its current weaknesses. We also discuss certain methodological approaches that have evolved over the last few years with emphasis on the work carried out by the authors, and outline needed approaches for further progress in this important field.