Membrane trafficking along the phagocytic pathway

BERÓN W; ALVAREZ-DOMINGUEZ C; MAYORGA L; STAHL PD

TRENDS IN CELL BIOLOGY

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 1995 vol. 5 p. 100 - 104

0962-8924

Phagosome maturation involves extensive remodelling of the phagosomal membrane as a result of intracellular transport events. Newly formed phagosomes exchange membrane-associated and soluble proteins with early endosomes by fusion. Budding of vesicles from the phagosome and fusion with Golgi-derived vesicles may also contribute to the remodelling o f the phagosomal compartment. As a consequence o f changes in membrane composition, phagosomes acquire the ability to fuse with late endocytic compartments. In vitro reconstitution and other studies suggest that the trafficking events underlying phagosome maturation require several GTP-binding proteins, including Rab5 and GαS, NSF-SNAP-SNARE complexes and coatomers.