Enantioselective hydrogenation of ethyl pyruvate with cinchonidine modified Pt/SiO2 catalysts

MARÍA F. IBÁÑEZ, GERARDO F. SANTORI, MÓNICA L. CASELLA, OSMAR A. FERRETTI

Journal of the Argentine Chemical Society

Asociación Química Argentina

Lugar: Buenos Aires, Argentina; Año: 2003 vol. 91 p. 63 - 72

0365-0375

In this work it was studied the enantioselective hydrogenation of ethyl pyruvate on Pt/SiO2 catalysts modified with a chiral compound, cinchonidine, and promoted with tin. The enantioselectivity of the nonpromoted Pt/SiO2 catalysts depends on the particle size; the higher the particle size, the higher is the enantiomeric excess. The addition of small amounts of tin (Sn/Pt = 0.01) produces a slight increment in the initial hydrogenation rate, and at the same time, a relative small change in the ee% value, but higher quantities of tin, generates a decrease in the initial hydrogenation rate, together with a marked diminution of the ee.