RyR phosphorylation in I/R-induced arrhythmias

MUNDIÑA -WEILENMANN C

San Diego, CA

Simposio; XXI Congreso mundial de la Sociedad Internacional de Investigaciones Cardiológicas (ISHR); 2013

Sociedad Internacional de Investigaciones Cardiológicas (ISHR)

Restoration of coronary flow after an ischemic event rescues the heart from further damage but also causes deleterious effect such as disturbances in heart rhythm. We analyzed the contribution of CaMKII-dependent phosphorylations to the generation of reperfusion arrhythmias. We found that CaMKII-dependent phosphorylation of the sarcoplasmic reticulum (SR) Ca-ATPase regulator phospholamban, is crucial in improving calcium handling and contractility during the reversible ischemia-reperfusion injury and that CaMKII-dependent phosphorylation of the SR ryanodine receptor is critical in the generation of arrhythmias. Maneuvers to prevent this latter one, will be beneficial in the treatment of reperfusion arrhythmias