INVESTIGADORES
MUNDIÑA Cecilia Beatriz
artículos
Título:
Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Autor/es:
MATTIAZZI A; MUNDIÑA WEILENMANN C; VITTONE L.
Revista:
Physiological Mini-reviews
Editorial:
Corpus
Referencias:
Lugar: Buenos Aires; Año: 2010
ISSN:
1669-5410
Resumen:
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β-adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
